Abstract The bio-ontology community falls into two camps: first we have biology domain experts, who actually hold the knowledge we wish to capture in ontologies; second, we have ontology specialists, who hold knowledge about techniques and best practice on ontology development.In the bio-ontology domain, these two camps have often come into conflic
Role of the ATPase/helicase maleless (MLE) in the assembly, targeting, spreading and function of the male-specific lethal (MSL) complex of Drosophila
Abstract Background The male-specific lethal (MSL) complex of Drosophila remodels the chromatin of the X chromosome in males to enhance the level of transcription of most X-linked genes, and thereby achieve dosage compensation.The revlon colorstay lip liner plum core complex consists of five proteins and one of two non-coding RNAs.One of the protei
Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and Leptin genes and up-regulation of the adiponectin gene
Abstract Background Endeavors to manage obesity have been heavily reliant on controlling energy intake and expenditure equilibrium, but have failed to curtail the overweight and obesity epidemic.This dynamic equilibrium is more complex than originally postulated and is influenced by lifestyle, calorie and nutrient intake, reward cravings and satiat
Optimizing Precision Medicine for Public Health
Advances in precision medicine have presented challenges to traditional public health decision-making paradigms.Historical methods of allocating healthcare funds based on safety, efficacy, and efficiency, are challenged in a healthcare delivery revlon colorstay lip liner plum model that focuses on individualized variations in pathology that form th
Comparison of Model Predictions and Laboratory Observations of Transgene Frequencies in Continuously-Breeding Mosquito Populations
The persistence of transgenes in the environment is a consideration in risk assessments of ashy bines protein powder transgenic organisms.Combining mathematical models that predict the frequency of transgenes and experimental demonstrations can validate the model predictions, or can detect significant biological deviations that were neither apparen